Low-dose naltrexone

Low-dose naltrexone (LDN) describes the off-label, experimental use of the medication naltrexone at low doses for diseases such as Crohn's disease and multiple sclerosis, but evidence for recommending such use is lacking.

Naltrexone is typically prescribed for opioid dependence or alcohol dependence, as it is a strong opioid antagonist. It has been suggested that LDN might operate as an anti-inflammatory agent and therefore be used to treat some chronic conditions such as chronic pain, but the research is still highly experimental and few studies have been replicated.

Some proponents of low-dose naltrexone have brought forth unproven claims about its efficacy in treating a wide range of diseases, including cancer, chronic fatigue syndrome and HIV/AIDS.