Platostoma menthoides

In Acute Oral Toxicity Study, no mortality was found at the end of study and sign of toxicity like change in skin and fur, eyes and mucous membrane, and also respiratory, circulatory, autonomic, and central nervous system and somatomotor activity, behavior pattern, sign of tremors, convulsions, salvation, lethargy, sleep, coma were also not found.Ethanolic extract of bark of Platostoma menthoides on yeast-induced pyrexia shown significant effect. Treatment with extracts at dose of 100 and 200 mg/kg body weight and paracetamol at dose of 25 mg/kg decreased the body temperature of yeast-induced rats. The results obtained from both standard- and extract-treated groups were compared with the control group. A significant reduction in the yeast-elevated rectal temperature was observed in the test drug. Percentage decrease in temperature by ethanolic extract of P. menthoides bark (100 and 200 mg/kg) and standard drug was found to be 1.40, 3.20, and 3.80 percentages, respectively.