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In enzymology, a 2-deoxyglucose-6-phosphatase (EC 3.1.3.68) is an enzyme that catalyzes the chemical reaction

2-deoxy-D-glucose 6-phosphate + H2O  2-deoxy-D-glucose + phosphate

Thus, the two substrates of this enzyme are 2-deoxy-D-glucose 6-phosphate and H2O, whereas its two products are 2-deoxy-D-glucose and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is 2-deoxy-D-glucose-6-phosphate phosphohydrolase. This enzyme is also called 2-deoxyglucose-6-phosphate phosphatase.

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